Mr Lembembe's neck and feet appeared to have been broken and his face, hands, and feet burned with an iron, Human Rights Watch (HRW) said.
The cause of the killing is not known, but Mr Lembembe is the latest activist to be targeted in Cameroon, the group added.
Homosexual acts are illegal in socially conservative Cameroon.
'Death threats'
"The police should not rest until the perpetrators of this horrific crime are brought to justice. President Biya should break his silence on the wave of homophobic violence in Cameroon and publicly condemn this brutal attack," said HRW researcher Neela Ghoshal in a statement.
Mr Lembembe, the executive director of the Cameroonian Foundation for AIDS, was a courageous activist who campaigned for equal rights, despite severe discrimination and violence, HRW said.
His friends discovered his body at his home in Yaounde on Monday, after being unable to reach him by phone for two days.
Cameroonian police have not apprehended a single suspect, although activists have reported all the incidents, HRW said.
In December, a Cameroon appeals court upheld the sentencing to 36 months in prison of Roger Jean-Claude Mbede under anti-gay legislation. His lawyer said he was sentenced simply for sending a text to someone to say he loved him.
In January, the appeals court overturned the conviction of two men jailed in 2011 for homosexual acts.
Homosexual acts are illegal in many African countries - including Uganda, which is considering imposing harsher penalties.
The US and European Union (EU) have threatened to cut aid to countries that fail to repeal legislation that outlaws homosexual acts.
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